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Often, no cause can be found for a low sperm count. However, it has been associated with several genetic and non-genetic conditions including:
  • A hormone imbalance such as hypogonadism.
  • An inherited genetic problem such as Klinefelter's syndrome, where a man is born with an extra female chromosome.
  • Undescended testicles.
  • A structural problem with the male genital tract.
  • A genital infection such as chlamydia, gonorrhea or prostatitis (infection of the prostate gland).
  • Antibodies that attack sperm.
  • Previous surgery to the scrotum or surrounding area.
  • Varicoceles (dilated veins within the testicles).
  • Certain medication, including testosterone replacement therapy, long-term anabolic steroid use, cancer medications (chemotherapy), some antibiotics and some ulcer medications.
  • Exposure to chemicals such as pesticides.
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